Protection Effect and Antioxidation of Polygonatum sibiricum Polysaccharide on Liver Function in Cisplatin-induced Hepatotoxicity Rats

Abstract:

Objective: To study the protection effect of Polygonatium sibiricum polysaccharide(PSP) on cisplatin-induced hepatotoxicity. Method: Forty Sprague-Dawley rats were randomly divided into normal control group,model group,the low dosage group,the middle dosage group and the high dosage group of PSP, with eight rats in each group. The model rats with hepatotoxicity were duplicated with injection of cisplatin(5 mg·kg^-1). The rats were injected with cisplatin(5 mg·kg^-1) after fifth days rats in the low, middle and high dosage group of PSP were treated by PSP 10,20,40 g·kg^-1 once a day. After 10 days of administration with PSP, the changes of liver coefficient were examined and the blood alanine aminotrans ferase(ALT), aspartate amino transferasen(AST), the activity of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and the content of malondialdehyde(MDA) was measured. Result: Compared with the normal control group, contents of ALT, AST in serum were significantly increased in each treatment group(P<0.01), the content of MDA was significantly increased(P<0.01) and the activity of SOD and GSH-Px was significantly decreased(P<0.01). Compared with the model group, contents of ALT, AST in serum were significantly decreased in each treatment group(P<0.05 or P<0.01), the content of MDA was significantly decreased(P<0.05 or P<0.01) and the activity of SOD and GSH-Px was significantly increased(P<0.05 or P<0.01). Conclusion: PSP may improve the function in liver injury rats induced by cisplatin and inhibite the oxidative damage of liver.