Protective Effects of Alcohol Extract of Kadsura heteroclita on Acute Hepatic Injury Induced by Carbon Tetrachloride in Rats

Abstract:

Objective: To observe the protective effects of alcohol extract of Kadsura heteroclita (Roxb) Craib on acute hepatic injury induced by carbon tetrachloride in rats. Method: SD rats were randomly divided into the normal group, model group, bifendate group, and alcohol extract of K. heteroclita low, middle, high dosage groups. In sixth day, other rats were injected subcutaneously with CCl₄ except the normal group with the same volume of saline after they were performed by gavage once a day and lasted for 7 days. After injected 24 hours, the contents of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in serum, the liver index and contents of reduced glutathione(GSH) in liver tissue were measured and the liver pathological changs were observed. Result: The alcohol extract of K. heteroclita decreased significantly the levels of serum ALT and AST and liver index, and increased the level of GSH (P<0.05 or P<0.01). The pathological changes were relieved in the treatment groups. Conclusion: The alcohol extract of K. heteroclita has protective effects on acute hepatic injury induced by carbon tetrachloride in rats.