Effect of Compound Phenytoin Sodium Gel on Restoration of the Wound’s Surface and Bacterial Infection

Abstract:

Objective: To observe the influence of compound phenytoin sodium gel (CPSG) for experimental animals on restoration of the wound's surface and bacterial infection. Method: The incised wound model of mice was established, CPSG (4.25,4.55 g·kg^-1)was external applied for 12 days and the wound contraction rate were observed after treatment for 3, 6,8,10, 12 days. Rats incised wound model accompanied by staphylococcus aureus were replicated, CPSG (1.70,1.82 g·kg^-1)was external applied for 12 d, and the wound recovery rate were detected after treatment for 3, 6,8,10,12 days. The histopathological changes of wound healing tissue were examined. Result: Compared with the wound contraction rate of gel group (16.77±4.79)%, (29.95±5.63)%,(50.69±4.19)%,(67.47±5.13)%,(82.48±4.40)%, those in low and high doses of CPSG were (20.16±5.78)%,(40.02±9.79)%,(71.04±7.27)%,(96.14±2.53)%,(99.44±1.30)%;(28.50±4.77)%,(55.66±8.39)%,(79.67±5.11)%,(96.14±2.53)%,(100.00±0.00)% respectively(P<0.05,P<0.01,P<0.01,P<0.01. P<0.01,P<0.01,P<0.01,P<0.01,P<0.01)after treatment for 3, 6,8,10,12 days in mice. The wound recovery rate of the low and high dose of CPSG were (29.45±5.11)%,(50.17±4.92)%,(72.48±5.05)%, (87.44±4.11)%,(96.66±3.75)%;(33.71±3.43)%,(58.67±5.59)%,(81.86±4.15)%,(95.92±2.39)%,(100.00±0.00)% higher than (20.71±3.58)%,(40.42±3.89)%,(58.53±6.21)%,(74.71±9.23)%,(86.47±7.15)% of gel group(all P<0.01)in the treatment of 3, 6, 8,10, 12 days. Conclusion: CPSG could promote the restoration of the wound's surface in the animals with experimental trauma and bacterial infection.