Effects of Extract from Persicae Semen Spatial Learning Memory and Anti-fatigue in Dementia Mice

Abstract:

Objective: To Study effect of ethanol extract from Persicae Seman on spatial learning memory and anti-fatigue in dementia mice induced by AlCl₃. Method: The mouse dementia model was induced by AlCl₃(200 mg·kg^-1,ig,40 d). Morris water maze test and the fatigue instrument were used to observe effect of ethanol extract malondial dehyde(MDA) contents and a cetylcholinesterase(AchE) activity in brain tissue were measured. Result: The ethanol extract from Persicae Semen(2.8 g·kg^-1) could significantly increase traversing times in 1 min platform. It can could improveanti-fatigue effect, and decrease MDA contents and AchE activity in brain tissue. Conclusion: The ethanol extract from Persicae Semen has improvement effect and anti-fatigue effect on spatial learning memory and anti-fatigue in dementia mice. Its mechanism maybe related to MDA contents and AchE activity.