Influence of Traditional Chinese Medicine Combined with Atorvastatin on Prognosis,Blood Lipid and Inflammation in Borderline Lesion Coronary Heart Disease

Abstract:

Objective: To explore the effect of traditional Chinese medicine combined with atorvastatin on prognosis, blood lipid and inflammation in borderline lesion coronary heart disease. Method: One hundred and fifty-six cases with borderline lesion coronary heart disease diagnosed by 64-row multi-detector computed tomography were randomly divided into control group and observation group. Two groups received both routine treatment and atorvastatin therapy, meanwhile, observation group was given warming yang promoting blood circulation treatment. Clinical effect, major cardiovascular event, blood lipid and serum inflammatory factors were compared between two groups. Result: The effective rate of treatment in observation group was 92.5%,which was much higher than that in control group (76.3%, P<0.05); major cardiovascular events were 16.3% and 38.2% in observation group and control group respectively with significant difference (P<0.05). After 6 months of treatment, total cholesterol(TC), triglyceride(TG) and low density lipoprotein(LDL-C) in observation group were much lower than those in control group (P<0.05); serum high-sensitivity C-creactive protein(hs-CRP), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) after treatment greatly decreased in control group and experience group,which in observation group were superior to control group (P<0.05). Conclusion: Traditional Chinese medicine combined with atorvastatin for borderline lesion coronary heart disease significantly decrease the blood lipid, serum inflammatory factors and major cardiovascular events.