Abstract:Objective: To observe the clinical effect of Shixiao san on 180 cases with reflux esophagitis. Method: One hundred and thirty cases with reflux esophagitis were randomly divided into 67 cases in treatment group and 63 cases in control group.Treatment group was treated with modified Shixiao san, while control group was treated with omeprazole and domperidone, then the clinical changes were observed. Result: In treatment group,the total effective rate was 76.1%.In control group,the total effective rate was 69.8%,there was remarkably difference between two groups (P<0.01). Conclusion: Shixiao san in treatment of reflux esophagitis has a demonstrable effect.