Investigation of Preparation Technology of Rhododendri Daurici Folium Total Flavonoids Solid Dispersions

Abstract:

Objective: To optimize preparation technology of Rhododendri Daurici Folium total flavonoids solid dispersions. Method: With polyethylene glycol 6000(PEG6000),polyvinyl pyrrolidone(PVPK30 K30) and poloxamer 188 (Pluronic F68) as carrier respectively,suitable carrier melting-solvent method and solvent method were used to prepare solid dispersions with different proportion(1:1,1:2,1:4,1:6) of total flavonoids from Rhododendri Daurici Folium-carrier.With total flavonoids from Rhododendri Daurici Folium as detection index,in vitro dissolution of the dispersions was analyzed by UV,and T_d of each solid dispersions was calculated. Result: Optimum preparation process was as following:with 4 times the volume of PVPK30 as carrier,dissolved in 20 times the amount of ethanol,rotary evaporation to remove ethanol at 50℃,in vitro dissolution of total flavonoids from Rhododendri Daurici Folium in PVPK30 solid dispersions were up to 100%.With PEG6000 as carrier,T_d of solid dispersions with different proportion(1:1,1:2,1:4,1:6) of total flavonoids from Rhododendri Daurici Folium-carrier were 6.329,5.225,0.096,4.755 min,respectively;Pluronic F68 as carrier,T_d were 4.045,3.561,0.018,0.026 min,respectively;PVPK30 as carrier,T_d were 5.000,5.000,0.005,0.056 min,respectively. Conclusion: Solvent method could successfully prepare Rhododendri Daurici Folium total flavonoids solid dispersions with good solubilization effect,but this method was not suitable for industrial production.