Extraction Technology Change and Pharmacological Test Verification of Tongmai Oral Liquid

Abstract:

Objective: To compare effects of different extraction processes for Tongmai oral liquid on experimental myocardial ischemia in mice. Method: Intraperitoneal injection of isoproterenol in mice to establish model of myocardial ischemia.Effects of Tongmai extract A,Tongmai extract B,commercially available Tongmai oral liquid and compound Danshen tablets on plasmic ATP content and myocardial tissue in mice were compared. Result: The concentration of plasmic ATP in model group,Tongmai oral liquid group,Tongmai extract A group,Tongmai extract B group,compound Danshen tablets group and blank control group were (197.06±77.78),(239.60±60.90),(328.21±84.27),(318.42±70.87),(271.13±66.45),(475.93±94.98) μg·L^-1,respectively;Myocardial tissue damage index of these groups were (2.26±0.86),(1.16±0.28),(0.59±0.17),(0.76±0.23),(0.68±0.12),0,respectively.Treatment effect of Tongmai extract A and Tongmai extract B were significantly better than Tongmai oral liquid and better than compound Danshen tablets without significantly influence,but Tongmai extract A was slightly better than Tongmai extract B. Conclusion: After changing of extraction processes,Tongmai extract A and Tongmai extract B could significantly improve myocardial ischemia in mice by increasing heart function,treatment effect was significantly better than commercially available Tongmai oral liquid,wherein Tongmai extraction A showed more significant role.