α-Glucosidase Inhibitory Activity of Extracts from Desmodium caudatum

Abstract:

Objective: To evaluate α-glucosidase inhibitory activity of extracts from Desmodium caudatum. Method: By establishing α-glucosidase inhibitory model in vitro, the activity of extracts from D. caudatum was screened. Result: The extracts from D. caudatum showed good inhibitory activity. The ethyl acetate extract and petroleum ether extract had higher inhibitor activity (IC₅₀=9.79 and 39.2 mg·L^-1), which showed far greater activity than that of acarbose (IC₅₀=1 103.01 mg·L^-1), and followed by petroleum ether and n-butanol extract (IC₅₀=625.1 mg·L^-1). The α-glucosidase inhibitory activity of DCBU had concentration-dependent manner. α-Glucosidase inhibitory activity of DCPE and DCEA is sensitive to the change of concentration, which increased dramatically as the concentration increased. Conclusion: DCPE and DCEA showed very significant inhibitory activity to α-glucosidase, and could be exploited the diabetes drugs as α-glucosidases inhibitors in future.