Abstract:Objective: This manuscript presents a method to research the dissolution and external leaching rule of Suxiao Zhixie capsule. Method: By using of HPLC method, the wavelength of the spectrophotometer set at 256 nm. The dissolution medium is 0.1 mol·L-1 HCl, the rotate speed is 120 r·min-1(settlement basket method). Result: We get a good uniform and repeatability during assaying the dissolution of Suxiao Zhixie capsule. The sampling time should be 45 min, and the percentage of dissolution should not less than 75%. Conclusion: The method we used to assay the dissolution of Suxiao Zhixie capsule is simple, accuracy and reliable.