Drug Evaluation of Bitterness Intensity by Three Kinds of THTPM

Abstract:

Objective: Compare characteristics of three kinds of THTPM(traditional human taste panel method) which is suitable for drugs bitter evaluation study. Method: As matrine a model drug, made into different concentration of aqueous solution. The training of qualified evaluators screened by 20 taste bitterness level,then make specific bitterness value.Three methods of evaluation of the sample were order evaluation methods, score evaluation method and integrated score evaluation method.After the data processing,comprehensive analysis of the four indicators integrate which was rate of right rank, decision sensitivity, precision of evaluate and fitting of degree. Result: Integrated score evaluation method whose rate of right rank was 100%,decision sensitivity was 96.4%,multiple correlation coefficient of Fitting Degree was 0.991 6 which is superior to other two methods through the three indicators.Moreover the score evaluation method was better than the other two methods in precision of evaluate. Conclusion: Integrated score evaluation method in the three methods of the tasting evaluation is the best though these four numbers of the indicators.But different experiment methods have its characteristics.Concrete tasting evaluation method is selected on the basic of the purpose of the experiment, the number of the sample and so on.