Effect of Polysaccharide from Spriulnia platensis on Mucosal Repair by Regulating the Expression of EGF and EGFR in Experimental Rats with Gastric Ulcer

Abstract:

Objective: To investigate the effect of polysaccharide from Spriulnia platensis(PSP)on expression of epidermal growth factor(EGF) and EGF receptor(EGFR) in mucosa of experimental rats with gastric ulcer, and to study the possible mechanism for therapy of stomach ulcer. Method: The gastric ulcer in rats was induced by acetic acid burning and treated with low and high dose of PSP separately for 15 days, the gastric mucosal thickness and muscularis mucosa defect were observed by HE staining, and the expression of EGF and EGFR were detected by immunohistochemical staining. Result: The ulcer in treatment group healed well compared with model group and control group, high dose of PSP could promote the healing of gastric ulcer, reduce muscularis mucosa defect significantly (P<0.01), increased the expression of EGF and EGFR observably. Conclusion: There is evident therapeutic effect of PSP on the experimental gastric ulcer in rats, and its mechanism might be related to the increasing EGF and EGFR protein expression.