Pathomorphological Change of Rats with Acute Myocardial Infarction and the Interfering Effects of Xuemaitong Capsule

Abstract:

Objective: To explore the pathomorphological changes of myocardial of rats with acute myocardial infarction and the interfering effects of Xuemaitong capsule(XMT). Method: The Wistar rats were randomized into 5 groups, the model group, the sham operation group, the three difference dose groups of XMT preconditioning. The model rats were treated by continuous 14 days intragastric administration. After 14 days, except the sham operation, myocardial infarction of the other groups were established by ligation of coronary artery.Before and after ligation, electrocardiogram were recorded in 5,30,60,90, 120 minutes, 24 hours;pathomorphological change were checked by HE staining. Result: Compared with the high dose, in middle dose and low dose group, the J point were decreased. Pathological alteration of myocardial infarction showed that myocardial endometrial focal disordered arrangement, muscle cells swelling or necrosis, adventitia focal necrosis, and infiltration of inflammatory cells. Compared high and middle groups to model group, the pathomorphological change were slightly among high and middle groups. By semi-quantitative, the pathomorphological changes proved to be true (P<0.05). Conclusion: XMT has important protective function for acute myocardial infarction.