Chinese Journal of Experimental Traditional Medical Formulae
Influence of Sinisan on ICAM-1 and VCAM-1 in Experimental Ulcerative Colitis Rats
Author:
Affiliation:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
    Abstract:

    Objective: To study Sinisan on intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesionmolecule-1(VCAM-1) in experimental (UC) rats. Method: The animals were divided into 5 groups, including the normal group, model group, Sini powder group, Chaishaozhi group and Chaishao group. The antigen emulsion made by fresh rabbit colonic mucosa were injected into the rats' bilateral paws, groins and backs in 1st, 10th, 17th, 24th day to induce model. The normal group and model group were given with 10 mL·kg-1 distilled water;and Sinisan group was treated with 1.75 g·kg-1 Sinisan solution;and Chaishaozhi group was treated with Chaishaozhi 1.31 g·kg-1 Chaishaozhi solution;and Chaishao group was treated with with 0.88 g·kg-1 Chaishao solution. On the 29th day, the rats were sacrificed and drawn. ICAM-1 and VCAM-1 levels were detected with ELISA. Result: ICAM-1 levels in blood of model group(64.60±4.81)μg·L-1 were higher than normal group(42.35±3.02)μg·L-1,P<0.05, and VCAM-1 levels(0.29±0.01)μg·L-1 higher than normal(0.20±0.02)μg·L-1,P<0.05.VCAM-1 levels in colon mucosal tissue of model group(1.82±0.19)μg·mg-1 higher than normal group(1.29±0.10)μg·mg-1,P<0.05.Sini san could significantly reduce ICAM-1(53.87±2.60)μg·L-1, VCAM-1(0.22±0.01)μg·L-1 levels in blood,and VCAM-1(1.41±0.08)μg·mg-1in colon mucosal tissue, P<0.05. Conclusion: The mechanism of intervening experimental UC by Sinisan is related to the balance of cytokine network.

    Reference
    Related
    Cited by
Get Citation
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:January 30,2013
  • Revised:
  • Adopted:
  • Online: October 13,2013
  • Published:

Address:

Postcode:100700

Phone:010-84076882

E-mail:syfjx_2010@188.com

® 2024 All Rights Reserved

Supported by:Beijing E-Tiller Technology Development Co., Ltd.