Protective Effect of Mongolian Medicine ’Lianqiao-4 Ingredient Soup Powder’ on Liver Injury Induced by Pylorus Ligation

Abstract:

Objective: To evaluate the effect of Mongolian medicine ‘Lianqiao-4 Ingredient Soup Powder' on the acute liver injury of rats caused by pylorus ligation. Method: Model of acute liver injury was induced by using pylorus ligation. After making model of 16 h indexes of alanine aminotransferase(ALT), aspartate aminotransferase(AST), nitric oxide(NO), nitric oxide composite enzyme(NOS), cholinesterase(CHE), urea nitrogen(URE), total cholesterol(CHO), triglyceride(TG), low density lipoprotein(LDL-C)in serum, liver index and pepsin in the stomach homogenate in the normal group, model group, Mongolian medicine ‘Lianqiao-4 Ingredient Soup Powder' low, middle, high dose groups(1.3, 2.6, 3.9 g·kg^-1)were determined respectively. Result: Compared with normal group, serum AST, ALT, BUN, NOS in the model group were increased significantly (all P<0.01);CHE, NO decreased significantly (P<0.05);MAO, CHO, TG, LDL-C level, liver index and activity of pepsin increased significantly (P<0.05). Compared with model group, AST, ALT, NOS, MAO, CHO, TG, LDL-C level, liver index and activity of pepsin in the high dose group of treatment were decreased significantly (P<0.05, P<0.01 respectively), CHE and NO increased significantly (P<0.05). Low dose showed some influences for all indexes, but without significant difference compared with model group. Conclusion: Significant protective action of Mongolian medicine 'Lianqiao-4 Ingredient Soup Powder' on the acute liver injury was found. And taking various elements into the comprehensive consideration, the middle dose group was the best.