Abstract:Objective: Discuss the clinical efficacy of Tongfu Runzao decoction of oral antidiabetic drugs in poorly controlled gastrointestinal-heat type 2 diabetes(T2 DM). Method: Divide the 120 cases of oral hypoglycemic drugs poorly controlled type gastrointestinal excess heat T2 DM into control group and observation group randomly,each group has 60 cases. Both groups were treated with recombinant insulin glargine,observation group took Relaxing moistening party additionally,therapy for eight weeks.Monitor fasting blood glucose after treatment.2 h postprandial blood glucose(2 hPG);test glycosylated hemoglobin before and after treatment,fasting insulin (FINS) and blood lipids;record the time of blood glucose,record usage of recombinant insulin glargine per week,record hypoglycemia occurred and gastrointestinal excess heat syndrome score. Result: The 2 hPG,HbA1c and FINS of the observation group is lower than the control group (P<0.05). The ISI of two groups both increased, while the significant increasing occurred in the observation group (P<0.01). Compared to the control group, the improvements of weight and waist circumference were all more obvious (P<0.05). During the 4, 6, 8 weeks after the treatment, the dose of recombinant insulin glargine of the observation group was all inferior to that of the control group (P<0.01). The average time (14.2±2.48) d of recovering blood glucose of the observation group was less than the time (17.8±2.79) d of the control group (P<0.01). The incidence of hypoglycemia and average people-time were both lower than the control group (P<0.01). Besides, after the treatment, the TG, TC and LDL-C level were lower than the control group excepting the HDL-C level higher than that of control group (P<0.05). The scores of the main symptoms (such as thirsty, like of cold drinks, distention and fullness and stool induration) were lower than control group (P<0.01). Conclusion: The Tongfu Runzao decoction can reduce the 2 hPG, HbA1c in the T2 DM, which could be controlled well by oral antidiabetic drugs, prompting the blood glucose of patients reaching the standard level. It can also decrease the usage of insulin, reducing the incidence of hypoglycemia caused by insulin. Can effectively improve the clinical symptoms, improve patient quality of life.