Abstract:Objective: Observed Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application treated severe acute pancreatitis (SAP) and effect of serum cytokines. Method: The 80 patients with SAP were randomly divided into control group and observation group. Each group had 40 patients. 2 groups were reference to the'Severe Acute Pancreatitis Treat Guide'. Fasting, gastrointestinal decompression, Supplemented the blood volume, corrected water electrolyte acid-base balance, somatostatin, omeprazole, antibiotics treated. Observation group in on the basis of the control group with Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application treated. The treatment lasted 7 d. Recorded abdominal pain, abdominal bloating remission, recovery of bowel sounds and ventilation defecation time, recorded the hemogram, blood, urine amylase recovery time and average hospitalization time and average hospitalization costs. Before and after treatment we tested serum interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-15 (IL-15) and tumor necrosis factor-alpha (TNF-α) levels. Result: The total effective rate of observation group was 97.5% better than the 80% of the control group (P<0.05);the observation group abdominal pain and abdominal bloating remission time, the recovery of bowel sounds time and the time of first defecation time were shorter than the control group (P<0.01);observation group, average hospitalization time and average hospitalization costs was less than that of the control group (P<0.01);the observation group normal hemogram time, blood, urine amylase recovery time were shorter than the control group (P<0.01);observation group serum IL-6, IL-15 and TNF-α level decreased significantly, and lower than the control group (P<0.01), the observed serum IL-10 significantly increased and higher than control group (P<0.01). Conclusion: Qingyi Chengqi decoction oral and Shuangbai Sanjie powder external application could be significantly improved with SAP in acute abdominal pain, bloating and other symptoms of intestinal paralysis, adjusted the level of serum inflammatory factors, relieved pancreatitis systemic damage, which would facilitate the rehabilitation of the disease.
