Reduning Injection and Atomization Inhalation Treatment of Bronchiolitis in 45 Cases

Abstract:

Objective: To discuss the clinical efficacy of treating pediatric capillary bronchitis with Reduning injection intravenous drip and Inhalation extra and the influence to inflammatory factors. Method: Ninety patients with pediatric capillary bronchitis were randomly divided into observation group (n=45) and control group (n=45). Patients in the two groups were both treated with conventional Western therapy. Patients in control group were treat with budesonide 1 mg and terbutaline 5 mg in physiological saline 5 mL by oxygen atomizing inhalation. Patients in observation group were given reduning injection intravenous drips and oxygen atomizing inhalation. Both groups were taken 7 day one cycle. The arterial blood gas index were recorded at 0 d and 3 days and the main symptoms and signs were recorded at 0, 3, 7 day;Serum interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) levels were tested before and after treatment. Result: The total efficacy of the observation group 96.6% was significantly better than the control group 82.2% (P<0.05). Oxygen saturation(SPO₂) and oxygen tension(PaO₂) were both significantly higher at 3 day and observation group was higher than control group. PaCO₂ of observation group was decline and was lower than control group(P<0.01). At 3 day, fever, cough, expectoration, wheezing suppress and lung auscultation score of observation group were lower than control group (P<0.01). At 3 day, cough, expectoration, wheezing suppress and lung auscultation score of observation group were lower than control group (P<0.01). Serum IL-6, IL-8 and TNF-α levels of observation group were lower than control group (P<0.01). Conclusion: Reduning injection intravenous micropump and inhalation extra has significant clinical efficacy and the mechanism may be related to reduce inflammation.