Effect of Bailing Capsule on T Lymphocyte Subsets in Patients with Graves’ Disease

Abstract:

Objective: To investigate the effect of Bailing capsule on T lymphocyte subsets in patients with Graves' disease(GD). Method: Sixty patients with GD were selected and randomly divided into 2 groups, routine group (n=30) was treated with Methimazole;the Bailing capsule group (n=30) was treated with Bailing capsule(4# Tid)combined with Methimazole. The levels of T-lymphocyte subsets,free triiodothyronine 3(FT3),FT4,sensitive thyroid stimulating hormone(sTSH),thyrotrophin receptor antibody(TRAb),interferon-γ(FN-γ),interleukin-4(IL-4) were measured in two group pre and post treatment.Follow-up 1 year after treatment,observe the recurrence rate of GD. Result: The thyroid function of the two groups was not significant after treatment. After treatment the CD4⁺T cells,CD4/CD8,IFN-γ,TRAb in the Bailing Capsule group [CD4⁺(30.6±2.1)%,CD4/CD8(1.5±1.7), IFN-γ(25.8±4.2)μg·L^-1, TRAb(18.2±10.6)U·L^-1] was decreased more significantly than routine group[(35.9±1.8)%,(1.7±1.3),(34.8±2.4)μg·L^-1,(25.9±8.8)U·L^-1]. After treatment the CD8⁺T cells and IL-4 in the Bailing capsule group was increased more significantly than routine group[CD8⁺(23.1±1.8)% vs (20.2±1.3)%, IL-4(14.8±3.2) μg·L^-1 vs(12.5±1.7) μg·L^-1] (P<0.05). Follow-up 1 year after withdrawal,the Bailing capsule group than the c routine group recurrence rate was significantly lower(16.7% VS40%)(P<0.05). Conclusion: The Bailing capsule can effectively regulate the GD patient's cellular immunity and reduce autoantibody levels in GD patients.