Meta Analysis of Shuxuetong Injection Combined with Ozagrel Sodium in Treatment of Acute Cerebral Infarction

Abstract:

Objective: It is to assess the curative effect and safety of Shuxuetong injection combined with Ozagrel Sodium injection in the treatment of acute cerebral infarction(ACI) with Meta analysis method. Method: The randomized controlled clinical trials of Shuxuetong injection combined with Ozagrel Sodium injection for the treatment of ACI from 1989-2012 were searched by computer-based on line search,and the data was statistically analyzed by Review Manager 5.1.7. Result: The results showed that there were 24 literatures which incorporated by Meta-analysis and the criterion were homogenous. Fixed effect model statistics and analysis showed that the OR(95%CI)was 4.30(3.16-5.86). WMD(95%CI)was-3.63(-4.85--2.41). Conclusion: Meta analysis shows that Shuxuetong combined with Ozagrel Sodium injection is effective for ACI and it can improve the clinlcal symptom and neurologic impairment in the treatment of ACI without obvious ADR. However,more strict and multicentric randomized double-blind control trials are needed in order to provide more convinced evidence.

Key words:Ozagrel Sodium;Shuxuetong injection;acute cerebral infarction;Meta analysis