Advance in Study of Anaphylactoid Reactions and its Experimental Models During Chuanxinlian Injections

Abstract:

Chuanxinlian injections are special in the treatment of some acute diseases and infectious diseases because of their rapid effect and high efficiency. However, more adverse reactions of Chuanxinlian injections, especially anaphylactoid reactions, have been reported along with their wide use in clinic recently. And the concerns to the safety of Chuanxinlian injections are much more focused. On the basis of the Chinese journal full-text data base, literatures about the adverse effects of Chuanxinlian injections were searched and investigated. The safety state of injection of Chuanxinlian injections was analyzed, and three kinds of detection model to anaphylactoid reactions:in vitro cell model, animal model of wild rodents and big animal model were summarized. We hope that paper could supply any research ideas for solving the safety problems of traditional Chinese medicine injection.