Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder

Abstract:

Objective: To investigate correlation between physical properties and yield pressure of traditional Chinese medicine powder and to find out main factors affecting compressibility. Method: Compressibility was characterized by yield pressure of Heckel equation.Correlation between physical properties including angle of repose,collapse of angle,flat angle,water content,bulk density,tap density,moisture absorption, average particle size and yield pressure were investigated by multiple regression analysis. Result: Yield pressure of model drugs was in range of 52.76-261.64 MPa,yield pressures of Galla Chinensis extract,Ophiopogonis Radix extract and Lysimachiae Herba extract were greater than other substances.Regression equation showed angle of repose,tap density,moisture absorption and average particle size were positively correlated with yield pressure in measured range,but collapse of angle,flat angle,water content and bulk density were negatively correlated with yield pressure in measured range. Conclusion: Physical properties of traditional Chinese medicine powder had great effect on compressibility,wherein impact of angle of repose,moisture absorption,tap density and average particle size was comparatively great.