Effect of Alcohol Extract from Coreopsis tinctoria on Blood Pressure and Contents of ET, AngⅡ, CGRP in Spontaneous Hypertension Rats

Abstract:

Objective: To observe the effects of the alcohol extract from Coreopsis tinctoria on blood pressure, the content of plasma endothelin (ET), angiotension Ⅱ (AngⅡ) and calcitonin gene-related peptide(CGRP) in spontaneous hypertension rats (SHR). Method: The spontaneous hypertension rats (SHR) were randomly divided into six groups, untreated control,high, middle, low dosage group of the alcohol extract from C. tinctoria(3.2,1.6,0.8 g·kg^-1), captopril group(4 mg·kg^-1) and du zhong tablet group(187.5 mg·kg^-1). Tail blood pressure were measured every week.After 4 weeks, the contents of plasma ET, AngⅡ and CGRP were detected by radioimmunity method respectively. The left ventricular weight index (LVWI) and cardiac index were monitored too. Result: Compared with model group,the blood pressure of all groups significantly lowered after 4 weeks (P<0.01).The LVWI of all groups was decreased, while the high dosage group and captopril group showed significant difference (P<0.01).The contents of ET and AngⅡ were decreased greatly (P<0.01) in the high,middle dosage group and captopril group, while the contents of plasma CGRP were increased in all group,but showed no significant difference. Conclusion: The alcohol extract from C. tinctoria could significantly reduce blood pressure and improve myocardial hypertrophy in SHR,which might be related to inhibiting RAS and improving the endothelial function.