Study of Effect for Qishe Fang in Model Rats Dorsal Root Ganglion PLA2, PGE2 Expression Based on Theory of Compatibility

Abstract:

Objective: To observe the model rat nerve root compression dorsal root ganglion neurons (DRG) inside phospholipase A₂(PLA₂), prostagland in E₂(PGE₂) content of expression for different demolition party of Qishe Fang(QSF) and to further explore the compatibility law. Method: The 352 three-month-old SPF SD male rats were randomly divided into 11 groups, each group were administered simultaneously take dorsal root ganglia with different time PLA₂ and PGE₂ contents were detected by ELISA. The results were compared by SPSS 18.0, To identify the sensitivity component in inflammatory changes. Thus revealing the compatibility of components QSF interaction law suppressing inflammation. Result: Different compatibility groups relative to the untreated group can significantly reduce the dorsal root ganglion PLA₂, PGE₂ levels P<0.01, but between different groups with varying degrees of inhibition of inflammation P<0.05. Conclusion: Description of the compatibility between the components there is a synergistic effect, statistics showed that monarch drug can play a leading role, the other components can enhance the efficacy for monarch drug,but all parties comply the best efficacy compare others, the result indicating the compatibility of science and rationality of all parties.