Study on General Pharmacology of Nanwuweizi Softcapsule

Abstract:

Objective: To observe the effects of Nanwuweizi softcapsule on nervous system in mice as well as respiration system and cardiovascular system in dogs. Method: Mice were given oral medicine with different doses (100,200,400 mg·kg^-1) of Nanwuweizi softcapsule, and general behavior, spontaneous locomotor test, cooperation movement ability and synergistic effect with pentobarbital-sodium in mice were observed. Anesthetized dog were given Nanwuweizi softcapsule via duodenum with different doses (50,100,200 mg·kg^-1) to observe the effect on respiration system and cardiovascular system in dogs. Result: Nanwuweizi softcapsule had no affect on mice's general behavior, rotating bar and balance beam activity, as well as canine respiration system and cardiovascular system, including frequence and depth of respiration, systolic blood pressure(SBP), diastolic blood pressure(DBP), mean blood pressure(MBP), heat rate(HR), T-wave, P-wave, PR, QRS, QT interval segment of electrocardiogram. It decreased the locomotor activity and had synergistic effect with pentobarbital-sodium in mice with shorter sleep latency and longer sleep lasting time. Conclusion: Nanwuweizi softcapsule had no significant effects on general behavior, cooperation movement ability in mice as well as respiration and cardiovascular system in dogs. Nanwuweizi softcapsule had suppressive effect on spontaneous locomotor test and synergistic effect with pentobarbital-sodium in mice, which was consistent with the hypnagogic activity of Nanwuweizi softcapsule.