Abstract:Objective: The purpose is to discuss clinical effect the mechanism of anti-inflammatory on Tongfengding capsule and Yishen Juanbi pill combined with leflunomide and methotrexate to treat active stage of rheumatoid arthritis(RA). Method: Sixty-three cases of patients with RA were randomly divided into control group (30 cases) and observation group (35 cases) according to digital method.The patients in control group took methotrexate (MTX),10 mg/time,once a week.taken orally,Leflunomide tablets (LEF),20 mg/time,1 does/day,taken orally;celecoxib capsule,0.2 g/time,1 does/day,taken orally.For patients in observation group,they took Tongfengding capsule on the basis of the control group,4 pieces/time,3 times/day,taken orally,Yishen Juanbi pill,12 g/time,3 does/day,taken orally.After the pain relief,patients stop taking celecoxib capsules.Besides number of taking drugs is changing.Tongfengding capsule took 2 pieces/time and Yishen Juanbi pill took 8 g/time.Treatment courses for two groups are 24 weeks.Record morning stiffness time, tenderness index,swelling index, hands grip strength,20 meters walking time and health assessment questionnaire score (HAQ).Detect erythrocyte sedimentation rate (ESR),c-reactive protein(CRP) and rheumatoid factor (RF) before and after the treatment.Test the level of serum tumor necrosis factor-α (TNF-α),serum adhesion molecule (ICAM-1) and interleukin 1 (IL-1)before and after the treatment. Result: The effective rate of active cavity radiometer 70 of observation group was 48.48% superior to control group (16.67%) (P<0.01), at fourteenth week, the improvement of morning stiffness time,rest pain,tenderness index and swelling index of observation group were superior to control group (P<0.01), at the twenty-fourth week, the further improvement of morning stiffness time,rest pain,tenderness index and swelling index of observation group were superior to control group (P<0.05),a twelve weeks and twenty-four weeks,the grade of disease activity score-28 (DAS28) were both lower than control group(P<0.01), the descend grade range of DAS28 of observation group was superior to control group(P<0.01), after treatment,the level of ESR,CRP and RF of observation group were superior to control group(P<0.01), the level of TNF-α.ICAM-1 and IL-1 were lower than control group(P<0.01). Conclusion: The activities of clinical symptoms that Tongfengding capsule and Yishen Juanbi pill were combined with modifying diseases drugs on rheumatoid arthritis at its active stage and can control the inflammatory response,and its comprehensive clinical effects was superior to simple western medicine treatment.
