Abstract:Objective: The discuss clinical effects and mode of Sanqi Zhigan pill on non-alcoholic fatty liver disease(NAFLD) of 59 cases abnormal liver function patients. Method: One hundred and sixteen cases of patients were randomly divided into control group (57 cases) and observation group (59 cases) by digital method. The both groups were meddled with non-drug referred to clinical practice guideline of non-alcoholic fatty liver disease.The patients in control group took polyene phosphatidyl choline capsule,2 pieces/time, 3 times/day,orally.Reduced glutathione tablets,200 mg/time, 3 times/day,orally.For patients in observation group,they took Sanqi Zhigan pill,5 g/time, 3 times/day,orally.The treatment course was 12 weeks for both groups.Monitor alanine aminotransferase (ALT),glutamic oxalacetic transaminase(AST),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterin (LDL-C).Examine liver and spleen B ultrasound before and after treatment.Measure the level of serum superoxide dismutase (SOD), tumor necrosis factor alpha(TNF-α) and interleukin-18(IL-18). Result: After the treatment, total effective rate of the observation group was 93.22%, superior to 77.19% of the control group(P<0.05).After the treatment, ALT,AST of both groups improved markedly(P<0.01), after often rate of ALT,AST in the two groups were fairly.Often rate of TC,TG,LDL-C and HDL-C in observation group were better than control group.B ultrasonic examined the degree of fatty liver better in both group after the treatment.Improvement of the observation group level was superior to the control group(P<0.05), patients in two groups got a higher serum SOD after the treatment.Observation group level was higher than the control group(P<0.05), the level of serum TNF-α and IL-18 got declined.Observation group is lower than the control group(P<0.05). Conclusion: Sanqi Zhigan pill can protect patients' liver function with abnormal liver NAFLD function.Besides improve blood lipid back to normal.Its mode of action may be related to elevate serum SOD level,lower TNF-α and IL-18.
