Progress on Chemical Basis and Compatible Mechanism of Sini Decoction

Abstract:

Literatures of Sini decoction in recent years were reviewed. In this paper, the studies on cardiotonic, antiarrhythmic effects of chemical components of Sini decoction are summarized. To illustrate the compatible mechanism of Sini decoction based on absorption and metabolism.The aim of this study is to reveal the rational and scientific connotations of compatibility of Sini decoction. Sini decoction is a simple Chinese classic herbal formula. There are various studies that reported the major active ingredients in these three herbs (Radix Aconiti Laterlis, Zingiber officinale Rosc and Radix Glycyrrhizae) has been widely used to treat cardiovascular diseases in clinics at home and abroad. So far, there is limited systemic research on chemical substances and compatible mechanism focused on absorption and metabolism of Sini decoction. Therefore, pharmacokinetics-pharmacodynamics (PK-PD) correlation, advanced analysis techniques (such as high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)) should have been carried out in order to seek the chemical basis in vivo, interpret the decreasing toxicity and increasing efficacy compatible mechanism, and to provide useful information for safe, effective use and re-evaluation of Sini decoction.