Investigation of Cryogenic Pulverization Properties of Faeces Trogopterori

Abstract:

Objective: To study powder properties of Faeces Trogopterori and investigate relativity between powder properties and in vitro dissolution behavior. Method: Faeces Trogopterori was crushed by vibration type low temperature ultrafine pulverizer, sampling every 3 min, particle size, specific surface area and porosity of samples were detected;With the content of total flavonoids as index, in vitro dissolution rate of Faeces Trogopterori powder was investigated, relativity between powder properties and in vitro dissolution behavior was analyzed. Result: With increasing grinding time, particle size decreased, specific surface area and in vitrodissolution rate increased;Powder size and in vitro dissolution rate had a good correlation.Grinding time of Faeces Trogopterori selected 21 min, but particle size of d_0.9 should choose was about 100 μm. Conclusion: After low-temperature ultrafine ground of Faeces Trogopterori, particle morphology and structurewas uniform with high dissolution rate, which was helpful forits subsequent evaluation of preparation process and quality control.