Effects of Shenqi Yixin Fang on Myocardial Structure and Cytokines in Doxorubicin-induced Chronic Heart Failure Rats

Abstract:

Objective: To observe the effect of the Shenqi Yixin Fang on cardiac function, plasma angiotensin Ⅱ(AngⅡ) and tumor necrosis factor-α(TNF-α) of chronic heart failure(CHF) rats. Method: Ninty male Wistar rats were randomly divided into six groups:normal control group, model group, enalapril control group, the Qili Qiangxin control group, the low dose of Shenqi Yixin Fang group(16.96 g·kg^-1·d^-1), the high dose of Shenqi Yixin Fang group(33.92 g·kg^-1·d^-1). Doxorubicin was used to induce CHF models, and the modelling rats were given drug intervention for 4 weeks.The echocardiography was used to measure cardiac function, plasma AngⅡ and TNF-α were measured by radioimmunoassay. Result: In model group the left ventricular end-systolic diameter (LVSD), left ventricular end-diastolic diameter (LVDD), left ventricular ejection fraction (EF), left ventricular fractional were shorten compared with normal control group(P<0.05). In treatment group, these indicators were improved compared with modek group (P <0.05). In treatment groups the plasma AngⅡ/TNF-α levels were reduced compared with the model group (P<0.05). Conclusion: The Shenqi Yixin Fang can improve myocardial tissue morphology, inhibit ventricular remodeling and improve cardiac function in CHF rats.