Abstract:Objective: To study the antithrombotic effect of Fufang Xueshuantong capsule. Method: The rats were randomized into model group, low, moderate and high dosages(0.375, 0.75, 1.5 g·kg-1·d-1) groups of Fufang Xueshuantong capsule and aspirin enteric-coated tablets(50 mg·kg-1·d-1) group, each group was ig administrated once every day for 7 days. One hour after the last administration, the vena cava inferior thrombus model and carotid arterio-venous bypass thrombus model were built, the effect of Fufang Xueshuantong capsule on wet weight and dry weight of thrombus, and thrombogenesis-inhibition rate in rats were observed. The carotid artery thrombus model wasestablished, meanwhile intragastric administration lasted 5 days. After the last administration, the effect of Fufang Xueshuantong capsule on wet weight and thrombogenesis-inhibition rate in rats were observed. The rats were given subcutaneous injection of epinephrine, ice-bath and reducing feeding was used to establish acute blood stasis model.The effect of Fufang Xueshuantong capsule on clotting time(CT), thrombin time(TT), and platelet aggregation function of rats was observed. Result: Compared with normal group, CT and TT of model group were decreased (P<0.01), the function of platelet aggregation was increased (P<0.01).Compared with model group, Fufang Xueshuantong capsule could decrease wet weight and dry weight of vena cava inferior thrombus and carotid arterio-venous bypass thrombus, reduce wet weight of carotid artery thrombus (P<0.05, P<0.01), prolong CT and TT (P<0.05, P<0.01), and inhibit platelet aggregation of rats (P<0.05). Conclusion: Fufang Xueshuantong capsule exhibits an evident antithrombotic effect probably through conditioning the coagulation function and platelet aggregation function.
