Influence of Qingchang Huashi Fang on ESR,PLT and D-dimer in Treatment of Patients with Ulcerative Colitis

Abstract:

Objective: To observe the therapeutic effect of Qingchang Huashi fang on patients with ulcerative colitis and the improvements of erythrocyte sedimentation tate(ESR), platelet(PLT) and D-dimer after treatment, in attempt to evalutate its impact on remission induction and improved coagulation indexes. Method: Fifty-nine patients diagnosed with mild or moderate active ulcerative colitis and belong to Shire Neiyun syndrome were divided into traditional Chinese medicine(TCM) treatment group and Mesalazine control group. Patients were treated by oral and enema with TCM in treatment group, while in control group with Mesalazine. Evaluate the total effective rate, the main symptom disappearance rate, colonoscopy curative effect and ESR, PLT, D-dimer indicators. Result: The total effective rate of Qingchang Huashi fang was higher than mesalazine (93.3% vs 79.3%, P<0.05), and the disappearance rates of hematochezia and diarrhea in treatment group were higher than those in contol group (82.8% vs 58.6%, 85.7% vs 60.0%, P<0.01). The improvement of colonoscopy was also superior to Mesalazine (P<0.05).The indicators of ESR, PLT were improved much more than those in contol group (P<0.05). Conclusion: Qingchang Huashi fang was superior to mesalazine in remission induction, relief of symptoms and improvement of coagulation indexes. But we had not found that Qingchang Huashi fang was better than mesalazine in the improvement of D-dimer.