Research on Ginseng Polysacchride Injection Add DC Treatment in Th1/Th2 of NSCLC and CRC Patients Under Theory of Treating Different Diseases with Same Method

Abstract:

Objective: To explore the mechanism of Ginseng Polysacchride injection(GPS) add dendritic cells(DC) effect on Th1/Th2 of non-small cell lung cancer(NSCLC) and colorectal cancer(CRC) patients. Method: Eight cases of NSCLC and CRC patients were divided into four groups randomly (NSCLC control group, NSCLC research group, CRC control group, CRC research group), 20 cases in each group. Using DC or GPS add DC treatment. Detect interferon-γ(INF-γ), interleukin-4(IL-4), IL-2 and IL-5 in the four groups before and after treatment. Result: Before and after treatment, Th1(INF-γ, IL-2)and Th1/Th2(INF-γ/IL-4, IL-2/IL-5) were increased and Th2(IL-4, IL-5)was decreased in four cancer groups(P<0.01). After treatment, Th1(INF-γ, IL-2) and Th1/Th2(INF-γ/IL-4, IL-2/IL-5) were showed:NSCLC research group>NSCLC control group and CRC research group>CRC control group(P<0.05);Th2(IL-4, IL-5) was showed:NSCLC control group>NSCLC research group and CRC control group>CRC research group(P<0.05). Conclusion: GPS add DC treatment has different degree of Th1/Th2 regulation in NSCLC and CRC patients, this is one of the mechanisms of treating different diseases with the same method;GPS have the assistant to DC in adjusting the immunity of cancer patients.