Influence of Shugan Huazhuo Jiangtang Decoction on Cure of Type 2 Diabetes Mellitus Insulin Sensitivity

Abstract:

Objective: Observe the influence and mechanism of Shugan Huazhuo Jiangtang decoction on type 2 diabetes mellitus (T2 DM) insulin sensitivity. Method: One hundred cases of patients with T2 DM were randomly divided into control group (50 cases) and observation group (50 cases) according to the hospital order.The patients in the control group took pioglitazone metformin tablets, 1 piece/time, 2 times/day.Patients in observation group took Shugan Huazhuo Jiangtang decoction based on control group's treatment, 1 does/day.Treatment courses for two groups continued 12 weeks.Measure weight(Wt), waist circumference(WC), fasting blood-glucose(FBG), fasting insulin(FINS), 2 h postprandial blood glucose(2 hPBG) and glycosylated hemoglobin(HbAlc). Calculate body mass index(BMI), homeostasis model assessment for insulin resistance (HOMA-IR), islet B cell secretion index and insulin sensitivity index(ISI).Detect serum leptin(LP), adiponectin(APN), interleukin(IL-6). Result: After treatment, the level of FBG, 2 hPG, HbA1c and FINS of the observation group were lower than that of the control group(P<0.01), and the level of BMI and HOMA-IR of the observation group were lower than that of the control group, the level of HOMA-IS and ISI were higher than that of the control group(P<0.01), the level of IL-6 and LP were lower than that of the control group, but the level of APN was higher than that of the control group(P<0.01). Conclusion: Shugan Huazhuo Jiangtang decoction can regulate glucose metabolism and reduce blood glucose of T2 DM patients, besides, it can also improve secretion function of beta-cell and improve insulin sensibility of bodies, the mode of action may be related to the relief of inflammation.