Liqi Huatan Qutan Method Treatment on Coronary Heart Disease Combine Hyperlipidaemia (Stasis Stagnation Syndrome) with 45 Cases

Abstract:

Objective: The purpose is to observe the clinical effects of Banxiao Baizhu Tianma decoction combined with Danshen decoction add and subtract treatment on coronary heart disease stable angina pectoris combine hyperlipidaemia(stasis stagnation syndrome).Beside, to observe the influence of these treatment on lipoprotein associated phospholipase A₂(Lp-PLA₂), α-granule membrane protein on platelet surface(GMP-140) and platelet maximum condensation rate (ADP). Method: Ninety cases of patients were randomly divided into control group (45 cases) and observation group (45 cases) by sequential order of outpatient. Both groups received basic treatment, including bayaspirin enteric-coated tablets, 0.1 g/time, 1 piece/day, taken sublingual buccal immunotherapy.Nitroglycerin tablets, 1 piece/day, taken buccally when necessary.For patients in control group, they took atorvastatin, 20 mg/time, 1 does/day, taken orally.Patients in observation group took Banxiao Baizhu Tianma decoction combined Danshen decoction, 1 does/day.Treatment courses continued 12 weeks.Detect blood lipid level, record attack frequency of angina pectoris each week and nitroglycerin tablet before and after treatment.Conduct electrocardiographic examination before and after treatment.Test the level of Lp-PLA₂, GMP-140, high-sensitivity C-reactive protein(hs-CRP)and ADP. Result: The total curative effective rate of electrocardiogram of the observation group was 82.0% superior to 60% of the control group(P<0.05), for the observation group, the time of stenocardia and the dosage of nitroglycerin tablets were both less than that of the control group(P<0.01), and the total curative effective rate of reducing lipid of the observation group was 95.6% higher than 91.1% of the control group, and there was no statistically significant difference, after treatment, the level of cholesterol(TC) and triglyceride(TG) of the observation group was lower than that of the control group(P<0.01), and there was no statistically significant difference between low density lipoprotein cholesterol(LDL-C) group and high density lipoprotein cholesterol(HDL-C) group, Besides, the level of Lp-PLA₂, GMP-140, hs-CRP and ADP of the observation group were all lower than that of the control group(P<0.01). Conclusion: It can ameliorate patients' level of blood lipid of when Banxia Baizhu Tianma decoction which combined with Danshen decoction was used in coronary heart disease and stable angina pectoris pooling hyperlipidemia, and it can also relief angina symptom, we can get comprehensive curative effect. What's more it can relief inflammatory factors, inhibit platelet aggregation, there is a preventive effect to adverse events coronary heart disease.