Chinese Medicine Multi-target to Reverse MDR Mechanisms of Lung Cancer

Abstract:

Review and analysis the progress of research in traditional Chinese herbal monomer and compound reversing lung cancer multi-drug resistance (MDR) mechanisms.Currently, traditional Chinese herbal monomer and compound achieve reversal of multidrug resistance in lung cancer primarily by reducing membrane transport proteins, decreasing tumor cell detoxification, repair, regulating signal transduction apoptosis genes, cell cycle, tumor extracellular matrix. These results indicate that traditional Chinese herbal to reverse drug resistance mechanisms of lung cancer characterized by a multi-target, with potential development value, but also for the treatment of cancer in clinical medicine provides a scientific foundation.