Investigation of in vitro Release Characteristics of Shuxiong Pulsatile Controlled-Release Dropping Pills

Abstract:

Objective: To investigate in vitro release characteristics of Shuxiong pulsatile controlled-release dropping pills (SPCDP). Method: Determination of dissolution was taken by small glass method, effects of dissolution medium and stirring rate on in vitro release behavior were investigated, then release mechanism and characteristics of pulsatile controlled-release dropping pills were explained. Result: Release behavior of SPCDP was influenced most greatly by pH value of dissolution medium.Release behavior of pulsatile controlled-release dropping pills was good in 0.1 mol·L^-1 HCl solution at the first 2 h and in phosphate buffer solution (pH 6.8) after 2 h with stirring rate of 100 r·min^-1 by small glass method at (37±0.5) ℃. Conclusion: Description of dissolution profiles suggested that first order equation was the most appropriate model to describe release kinetics of SPCDP, this preparation had excellent characteristics of controlled-release formulation.