Track the Content Change of Three Kinds of Lactones in the Process of Chuanxinlian Injection

Abstract:

Objective: To strength the quality control method of Chuanxinlian injection by determining the content of andrographolide, neoandrographolide and dehydroandrographolide in the process of production. Method: Adopt UV-HPLC to track the dynamic variation of andrographolide, neoandrographolide and dehydroandrographolide in six key process steps, which were picked up from Chuanxinlian injection production process. And metastasis rate of 3 kinds of lactones were analyzed. Result: During the production, the metastasis rate of Andrographolide, neoandrographolide and dehydroandrographolide is different. It is 56.3%, 74.0% and 42.5% respectively. The metastasis rate of three kinds of lactones in different production process is different. The loss in the progress of decolorization activated carbon is most serious. And the metastasis rate of three kinds of lactones is only 75.2%. Conclusion: This research may give a mind of Chuanxinlian injection quality control change from static control to dynamic control. And a great number of possible quality problems in the process of production may be analyzed and summarized more accurate. It provides a solid scientific experimental basis for practical production of Chuanxinlian injection and feasible recommendations for related manufacturing enterprises. Therefore, this paper could offer a new thought for quality control of Chuanxinlian injection even traditional Chinese medicine injections.