Metabolites of Mangrove Endophytic Fungus ZH-4d from South China Sea

Abstract:

Objective: To study secondary metabolites of mangrove endophytic fungus No·ZH-4d from the south china sea. Method: The compounds were isolated by column chromatography and identified on the basia of physic-chemical constants and spectral analysis. Result: Six metabolites were obtained and elucidated as citrinin (1), tenellic acid C (2), tenellic acid A (3), terretonin (4), echinulin (5), (E) -4, 6-dimethoxy-3-[4-oxo-5-(prop-1-enyl)-4H-pyran-2-yl]-isobenzofuran-1 (3H)-one (6). In the preliminary bioassay, 1 show strong inhibittory activity on the KB, KBv200 with IC₅₀ values of 0.08, 0.09 mmol·L^-1, respectively. Conclusion: The six metabolites were obtained from endophytic fungus No·ZH-4d for the first time.