Dose-effect Relationship of Maxing Shigan Decotion in Anti-asthmatic Effects

Abstract:

Objective: To discuss the dose-effect relationship of maxingshigan decotion (MXSGD) in anti-asthmatic effects, and reveal characteristics of dose-effect relationship of Chinese compound preliminarily. Method: The influences of the 9 dose groups of MXSGD on the histamine phosphate induced asthma in guinea pigs were recorded and analyzed by the biological signal collection system, its dose-response curve was drawn in a dose as abscissa, effect as ordinate and the dose-effect relationship of multiple linear regression analysis. Result: MXSGD 1.33, 3.0, 10.13 g·kg^-1 could significantly prolong the incubation period of asthma (P<0.05), the dose-effect relationship between the asthma incubation period of equationwas Y=86.31+1.2X-0.063X²;MXSGD could significantly shorten the duration of asthma (P<0.05 or P<0.01), the dose-effect relationship equation asthma duration effect Y=13.99+0.44X-0.014X². Conclusion: The dose-effect relationship of maxingshigan decotion in anti-asthmatic effects is a non-linear, with the increase of the dose, indexes of effect on asthma animal model is increased.