Abstract:Objective: Investigate Dalitong granule the clinical effect the influence to motilin, gastrin and electrogastrogram when be used in diabetic gastroparesis (DGP). Method: Ninety patients were randomly divided into control group (45 cases) and observation group (45 cases).And setting pure diabetes mellitus (DM) as control group (15 cases).Patients in the two groups were treated with conventional treatment. Patients in the control group were treated with itopride hydrochloride tablets, 50 mg/time, 3 times/d, taken before meals.Patients in the observation group were treated with Dalitong granule, 6 g/time, 3 times/day, taken before meals.the treatment courses of the two groups were both 12 weeks.Before and after treatment, determining the level of plasma motilin and gastrin by radioimmunoassay. Determining electrogastrogram, recordding main symptoms and sign grade before and after treatment. Result: The total effective rate of the observation group was 91.11% superior to 73.33% of the control group (P<0.05), Before treatment, the level of plasma molitin and gastrin of the two groups were both higher than those of the pure diabetes mellitus (DM) group (P<0.01), after treatment, the level of plasma molitin and gastrin of the observation group were lower than those of the control group (P<0.01), and the dominant power before meal, main frequency of the observation group were both higher than those of the control group, the rate of bradygastria was lower than that of the control group (P<0.01), after treatment, the main symptoms and sign score of the two groups both decreased (P<0.01), and for the observation group, the main symptoms and sign score were both lower than those of the control group (P<0.01). Conclusion: Dalitong granule for the DGP patients, it can promote peristole, improve motive power of the stomach, and there was regulation gastrointestinal hormone and a certain degree of clinical efficacy.
