Discussion About Bufei Huoxue Decoction Combined Salmeterol Fluticasone Treatment on Chronic Obstructive Pulmonary Disease in o Curative Effect and Action Mechanism

Abstract:

Objective: The purpose is to discuss the efficacy of Bufei Huoxue decoction combined Salmeterol Fluticasone on cure of chronic obstructive pulmonary (COPD) curative effect and the influence of α₁-antitrypsin (α₁-AT) and interleukin-8 (IL-8). Method: The 72 patients diagnose clearly with COPD were randomly divided into control group and observation group. Each group were (36 cases). Both groups were given western medicine treatment as routine oxygen, eliminating phlegm et.Patients in control group took Salmeterol Fluticasone, 1 inhalation/time, 2 does/day.on the basis of the control treatment, patients in observation group plus therapy of Bufei Huoxue decoction, 1 does/day.Treatment courses for the two groups continued 12 weeks.Detect lung function, evaluate athletic ability by 6 min walking distance (6 MWD) and adopt COPD life quality scale (CAT questionnaire) to evaluate life quality before and after treatment.Besides test the level of α₁-AT and IL-8 around treatment. Result: Analyzing by Ridit, the total curative effect of the observation group was superior to the control group (P<0.05), after treatment, forced vital capacity (FVC) of the observation group, the FEV₁ volume of the observation group and FEV₁/FVC were all higher than that of the control group (P<0.01), after treatment 6 MWD of the observation group was superior to the control group (P<0.01), and the grade of CAT of the observation group was lower than that of the control group (P<0.01), and alpha 1-antitrypsin of the observation group was higher than that before therapy (P<0.01), which higher than that of the control group (P<0.01), Besides, the level of Serum IL-8 of the two groups were lower than that before therapy (P<0.01), and level of Serum IL-8 of the observation group was lower than that of control group (P<0.01). Conclusion: At the COPD stable phase, it can improve patients' lung function when Bufei Huoxue decoction combined with Salmeterol Fluticasone, and improve the exercise capacity and quality of life of patients, there was a significant curative effect, and the mechanism of action may be related to inhibiting inflammatory response.