Gengnianling Decoction Effects on of Women in Menopausal Syndrome Cure and its Influence on Endocrine Immune System

Abstract:

Objective: Gengnianling decoction clinical effects on of women in the menopausal syndrome (MPS) (yin deficiency of liver and kidney) cure and its influence on nerve-endocrine-immune network. Method: Eighty-six cases of patients with MPS yin deficiency of liver and kidney were randomly divided into control group (43 cases) and observation group (43 cases) according to digital method.Both groups were received properly psychological counselling treatment, diet and exercise guidance.Patients in the control group took Kuntai capsule, 4 pieces/time, 3 times/day.Patients in observation group took Gengnianling decoction, 1 does/day, decoction is taken 2 times. Treatment for two groups 12 weeks.Record KI scores, test the levels of serum estradiol (E₂), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) before and after treatment.Detect the level of plasma β-endorphin (β-EP), interleukin-2 (IL-2) and 5-hydroxytryptamine (5-HT) around treatment. Result: The total effective rate of disease curative effect in the observation group was 100% superior to 81.4% of the control group (P<0.05).After treatment, the KI (Kupperman index) scores of the two groups were both lower than those before treatment, and he KI scores of the observation group was lower than that of the control group (P<0.01).Besides, severity condition classification of the illness of the two groups both relieved (P<0.01), and severity condition classification of the illness of the observation group was lighter than that of the control group (P<0.05).E₂ level of the two groups both increased obviously, and E₂ level of the observation group was higher than that of the control group (P<0.01).The level of FSH and LH of the two groups both decreased, and the level of FSH and LH of the was lower than that of the control group (P<0.01).the level of β-EP, 5-HT and IL-2 of the observation group were higher than those of the control group (P<0.01). Conclusion: Gengnianling decoction can regulate the liver kidney yin deficiency syndrome of menopausal patients with nerve-endocrine immune network function, has better clinical curative effect.