Abstract:The stephania tetrandra, which contains tetrandrine and fangchinoline, is traditionally used as ananalgesic, antirheumatic, and antihypertensive drug in China. Recently, chemical composition and pharmacological activities of stephania tetrandra have been widely reported.Pharmacological experiments and clinical reports show that stephania tetrandra has multiple pharmacological activities, including anti-tumor, altered muhidrug resistance, neuroprotection and so on.Based on the research literature, this review will focus on recent developments concerning the pharmacology of stephania tetrandra, it shows a good prospect to make good use of its effective components.