Formulation Screening and Solubility Determination of Auraptene Dispersible Tablets

Abstract:

Objective: To optimize formulation process of auraptene dispersible tablets and evaluate its in vitro dissolution. Method: With angle of repose,hardness and disintegration time as indexes,effects of cross-linking polyvinyl pyrrolidone(PVPP),microcrystalline cellulose(MCC),pregelatinized starch(PRS),low substituted hydroxypropyl cellulose(L-HPC),sodium carboxymethyl starch(CMS-Na) and other excipients on formulation process were investigated.In vitro dissolution of dispersible tablets was determined by HPLC,mobile phase of methanol-water(95: 5),detection wavelength was set at 325 nm. Result: Optimal formula was as follows:auraptene 10 g,MCC 40 g,L-HPC 20 g,PVPP 10 g,CSM-Na 20 g,PRS 30 g,amylum 20 g;dispersible tablets disintegrated uniformly in 1 min,cumulative dissolution of this drug was more than 85% within 30 min. Conclusion: These prepared auraptene dispersible tablets have a fast,homogeneously dispersing profile and good releasing characteristics,which is suitable for clinical application.