Studies on Metabolic Substances of Zuogui Wan in Serum of Rats

Abstract:

Objective: To analyze the metabolic characteristics of Zuogui Wan in serum of rats. Method: The technology of nuclear magnetic resonance (NMR) was used to get metabolite fingerprint data of Zuogui Wan in serus, and the orthogonal partial least-squares discriminant analysis method was used to study the difference of the metabolite profile between Zuogui Wan containing serum and blank serum,then the variable importance in projection (VIP) and t test was to show the potential biological metabolites in serum. Result: There were significant differences in the pyruvate, lactic acid, low density lipoprotein and ethyl acetate and other material between Zuogui wan containing serum and blank serum. Conclusion: The variation of pyruvate, lactic acid, low density lipoprotein and ethyl acetate and other material in rats after giving Zuogui Wan containing serum can change the energy metabolism and cause the improvement of metabolism function.