Preventive Effect of Xuesaiton and Ginaton Injections on Cerebral Ischemia Reperfusion Injury of Rats

Abstract:

Objective: To observe the preventive effects of Xuesaitong and Ginaton injection on cerebral ischemia reperfusion(I/R) injury in rats. Method: Hundred and thirty SD male rats were divided into low dosage (25 mg· kg^-1) and high dosage (50 mg· kg^-1), of Xuesaitong and Ginaton injection, sham-operation and model groups.The volume of cerebral infarction, behavioral score, weight, mortality, superoxide dismutase(SOD), malondialdehyde(MDA), glutathione-S-transferase(GSH-S-transferase), nitrogen oxide(NO), NO synthase(NOS), xanthine oxidase(XOD), C-reactive proein(CRP) were determined to evaluate preventive effect. Result: Low Xuesaitong dosage had no effect on volume of cerebral infarction,behavioral score at 4, 24 h, mortality, SOD, GSH, NO and NOS, but it could reduce MDA content significantly. High Xuesaitong dosage had no effect on behavioral score at 4 h, mortality, SOD, MDA, NO, NOS, CRP, but it could reduce behavioral score at 24 h, volume of cerebral infarction, GSH. The low Ginaton dosage had no effect on weight,behavioral score at 4,24 h, mortality, MDA, SOD, GSH, NOS, but it could reduce volume of cerebral infarction, NO content significantly;the high dosage had no effect on MDA, SOD, GSH, NO, CRP. It could reduce behavioral score at 4, 24 h, volume of cerebral infarction, NOS and XOD activities significantly. Conclusion: The high dose Xuesaitong and Ginaton might be more effective than low dosage in reducing cerebral ischemia reperfusion injury. No significant difference was observed between Xuesaitong and Ginaton in a same dosage.