Effects of Wuzi Chengqi Decoction on Hyperuricemia Rats

Abstract:

Objective: To observe the effects of Wuzi Chengqi decoction on hyperuricemia rats. Method: Sixty SD male rats were divided randomly into 6 groups: normal control, model control, positive control, Wuzi Chengqi decoction high, middle and low dose groups(104, 52, 26 g· kg^-1). The hyperuricemia rat models induced by adenine(100 mg· kg^-1,ig,qd×28 d) and potassium oxonate (250 mg· kg^-1,ip,qw×4weeks). High, middle and low dose groups were given Wuzi Chengqi decoction 104, 52 and 26 g· kg^-1,ig respectively.After 4 weeks of modeling,the rats in each group of serum uric acid (UA),blood urea nitrogen (BUN),serum creatinine(SCr),xanthine oxidase (XOD),urinary UA and renal indices were examined. Result: Compared with normal group, UA in urine was decreaed, while UA, XOD,Cre and BUN in serum were increased significantly (P<0.01). The content of urine uric acid of low,middle and high dose groups were (146.3±22.5), (202.2±53.8),(218.1±62.6) μmol· L^-1 respectively,which was significantly higher than those of the model group (89.8±27.1)μmol· L^-1(P<0.01,P<0.05). The content of serum uric acid of low,middle and high dose groups were (207.3±42.5),(177.1±50.5),(158.0±49.0)μmol· L^-1 respectively,which was significantly lower than those of the model group(285.0±54.1)μmol· L^-1(P<0.01,P<0.05).Wuzi Chengqi decoction also could significantly inhibited the serum XOD activity,decrease the content of serum SCr and BUN(P<0.01,P<0.05). Conclusion: Wuzi Chengqi decoction has good preventive and therapeutic effect on hyperuricemia rats induced by adenine and potassium oxonate.