Influence of Shenqi Fuzheng Injection Combined with Sanshenqi Oral Liquid on Cellular Immunity Function in Cervical Cancer Patients with Postoperative Radiotherapy

Abstract:

Objective: To observe the influence of Shenqi Fuzheng injection combined with Sanshenqi oral liquid on patients' T lymphocyte subsets, natural killer (NK) cells and T helper type 1 (Th1)/T helper type 2 (Th2) cells in patients with radiotherapy after cervical cancer operation. Method: Seventy-eight patients were randomly divided into control group (39 cases) and observation group (39 cases) by random number table. Patients in control group received universality hysterectomy operation, then received drill⁶⁰ for entire pelvic external radiotherapy (5 000 CGy/25 times for 5 weeks) plus iridium¹⁹² for intracavitary radiotherapy to point A (600-700 CGy time/week for 4 weeks). Based on the treatment of control group, patients in observation group added Shenqi Fuzheng injection by intravenous drip (250 mL/time for 21 day periods of treatment separated by 7 days without treatment) and Sanshenqi oral liquid (20 mL/time, twice daily). All patients received 12 week period of treatment. Levels of T-lymphocyte subsets of peripheral blood (CD3⁺, CD4⁺,CD8⁺and CD4⁺/CD8⁺) and NK cells, and levels of interferon-γ (IFN-γ), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10) were detected before and after the treatment. Scores of qualities of lives were graded by Karnofsky Performance Status (KPS) scale. Result: After treatment, the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺and NK cells in observation group were increased (P<0.01), and which were higher than those in control group (P<0.01). The level of CD8⁺in observation group was decreased (P<0.01), and which was lower than that in control group (P<0.01). Levels of IFN-γ, IL-2 in observation group were higher than that in control group(P<0.01). Levels of IL-4, IL-6 and IL-10 in observation group were lower than those in control group (P<0.01). KPS score in observation group was (76.4±7.6), which was superior to that in control group (70.5±6.8) (P<0.01). The effective rate of life quality in observation group was 87.2%, which was higher than that in control group 64.1%, (P<0.05). Conclusion: Shenqi Fuzheng injection combined with Sanshenqi oral liquid can improve the life qualities of patients with radiotherapy after cervical cancer operation. Moreover, it can improve patients' immune function and there was a certain advantage in treating cancer treatment.