Influence of Bushen Jiansui Decoction on Treating Spinal Cord Injury During Recovery Period

Abstract:

Objective: To discuss the curative efficacy of Bushen Jiansui decoction in treating recovery of spinal cord injury (SCI) and the influence on inflammatory response of microcirculation. Method: Sixty-four patients with SCI were divided into control group (32 cases) and observation group (32 cases) using stratified blocked randomization. Patients in control group received rehabilitation training such as bladder functional training and toilet training, and patients with central pain took 20 mg tofluoxetine capsules orally once daily and 50 mg pethidine hydrochloride tablets 2 to 3 times daily according to their conditions. Patients in control group also received electroacupuncture treatment. Based on the treatment of control group, patients in observation group added Bushen Jiansui decoction. Patients in two groups received 8-week course of treatment. Lower urinary tract symptoms (LUTS) was graded. Extend dataset of bowel function of international SIC was evaluated. And pain was evaluated by short-from of McGill pain questionnaire (SF-MPQ). Thromboxane A₂(TXA₂), plasma endothelin-1 (ET-1), serous nitric oxide (NO) and intercelluar adhesion molecule were detected before and after the treatment. Result: ① Neuropathic bladder curative effect:LUTS scores in observation group were inferior to that in control group after the treatment (P<0.01). The improvement of voiding dysfunction in observation group was superior to that in control group via Chi-square test order information (P<0.05). ② Neurogenic bowel dysfunction curative effect:the number of patients with abdominal distension, constipation, drug dependence in observation group was less than theose in control group after the treatment (P<0.01). Besides, defecation time in observation group was shorter than that in control group (P<0.01). ③ Pain curative effect:PRI,VAS, PPI and total scores in observation group were lower than those in control group (P<0.01). ④ Microcirculation inflammatory effect:Levels of TXA₂, ET-1 and ICAM-1 in observation group were lower than those in control group, while the NO level in observation group was higher than that in control group after the treatment (P<0.01). Conclusion: Based on routine rehabilitation therapy, adopting Bushen Jiansui decoction can promote neuropathic bladder and bowel dysfunction recovery, reduce central pain with spinal cord injury patients. Its action mechanism may be related to improving microcirculation and inhibiting inflammatory reaction.